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obServation of clinical rouTine caRe of hEart failure pAtients iMplanted with BIOTRONIK CRT devices


  • long term assessment of outcome, efficacy and residual risks of CRT in an unsettled, real-life clinical set up
  • Find possible predictors for heart failure events
  • Identify areas of improvement for CRT and for CRT settings
  • Create generic registry as a platform for future registry – based trials and analyses, which will address specific scientific topics and safety aspects

In summary – collecting long term data for CRT in real-life population

Non – randomised, non-controlled, unblinded, multicentre international study

  • 5 year enrolment period
  • Target 3000 patients CRT-D, CRT-P 
  • Expected average follow up 42 months 


  • Planned implantation or upgrade to CRT for intended treatment according to guidelines
  • Willing to use the CardioMessenger and accepts the Home monitoring concept


  • Standard contraindication for CRT (?atrial fibrillation)
  • Already implanted with CRT
  • Pregnant or breastfeeding


  • MACE
  • All cause hospitalisations
  • All cause mortality
  • NYHA classification
  • LVEF
  • LV end systolic volume 
  • Exercise tolerance
  • Chronotropic incompetence
  • QOL self assessment

Number of Canberra Heart Rhythm patients involved in BIO STREAM – HF Study: 16

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